|
KMID : 1035520220100030135
|
|
Brain Tumor Research and Treatment : BTRT
2022 Volume.10 No. 3 p.135 ~ p.143
|
|
|
Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments
|
|
Ahn Jae-Hyun
Shin Christopher
Kim Yeo-Song
Park Jae-Sung
Jeun Sin-Soo
Ahn Stephen
|
|
|
Abstract
|
|
|
|
Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have suggested the potential benefits of cytotoxic T lymphocyte or dendritic cell-based vaccines for recurrent or newly diagnosed glioblastoma patients, several studies did not at all agree with the existence of CMV in glioblastoma cells. In this review, we summarized the conflicting results and issues about the detection of CMV in glioblastoma or glioma patients. We also provided the clinical data of published and unpublished clinical trials using CMV-specific immunotherapy for glioblastomas.
|
|
|
KEYWORD
|
|
|
Glioblastoma, Cytomegalovirus, Immunotherapy, Adoptive cell transfer, Cancer vaccines
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|